Category: Biochemistry 12
Gout In gout the urate crystals accumulates in synovial fluid. The above conditionl eads to inflammation mediated acute arthritis. The solubility of uric acid is lowered to 4.5 mg/dl …
Disorders of purine metabolism The most common abnormality of purine metabolism is elevation of uric acid level in blood. Elevated level of uric acid in blood is called as …
Biosynthesis of purine nucleotides Purine nucleotides are synthesized in cytoplasm of most of the tissues. The major site for purine synthesis is liver. Since purine ring are synthesized from …
Metabolism of Nucleotides Nucleotide metabolism involves several interconnected pathways. Nucleotides can be synthesized de novo, or from components “salvaged” from the degradation products of nucleic acids. When in excess, …
Characteristics of nucleic acids (a) The components of nucleic acids are nucleotides joined by phosphodiester linkage to one another. (b) Based on the type of sugar in nucleic acids, …
Ribosomal RNA (rRNA) Ribosomal RNA are found associated with large number of proteins in an ordered complex. Ribosomal RNA has a helical structure resulting from the folding back of …
Transfer RNA (tRNA) The length of tRNAs ranges from 65-110 nucleotides with a corresponding molecular weight of 22, 000-37500 Daltons. The tRNA is a single stranded. As a result …
Messenger RNA (mRNA) The structure of messenger RNA (mRNA) especially the eukaryotic mRNA has some unique. The 5’terminus of mRNA is “capped” with a methylated base of Guanosine 5’ …
