“Clinical Chemistry-Urea- ” Biochemistry Notes for Class 12 Complete Notes for Class 12

Urea

 Blood urea nitrogen (BUN)

The liver produces urea in the urea cycle as a waste product of the digestion of protein. Normal human adult blood should contain between 6 to 20 mg of urea nitrogen per 100 ml. Individual laboratories may have different reference ranges,
and this is because the procedure may vary.

 Interpretation

BUN is an indication of renal health. Normal ranges 8-20 mmol/L. If Glomerular Filtration Rate (GFR) and blood volume decrease (hypovolemia) then BUN will increase. Other factors responsible for its increment are fever, increased catabolism, high protein diet and gastrointestinal bleeding.

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